our understanding of the biology of depression, and especially on the role of the immune system and inflammation In some people, depression might be related to a chronic inflammatory response to stress, involving both like all other disorders: not just in the mind, not just in the brain, but in the whole body, with inflammation Second, new anti-inflammatory treatment strategies, targeting inflammation through medications, nutritional lifestyle changes, are currently been developed for the specific subgroup of patients with increased inflammation

Now a little bit about depression in the context of inflammation, since this was what primarily ignited Over the past few decades, clinical studies have shown that increased systemic inflammation (measured As the activity of the endocannabinoid system increases, it reduces inflammation. inflammation. I was curious and the questions I asked myself were whether increased systemic inflammation increased

focusing on relevant biological mechanisms for the development of cardiometabolic diseases, such as inflammation patients to offer treatments targeting specifically the identified altered biological mechanisms, such as inflammation We are currently testing this approach in the INFLAMED clinical trial at our department, that I am leading This study aims to test the efficacy of adding an anti-inflammatory medication in the treatment of a subject selected with criteria in line with those of IMD, such as high levels of inflammation and depressive

Carmine Pariante and his team have shown that prenatal depression disrupts the immune system, triggering inflammation Depression, inflammation, and pregnancy all intertwine, affecting the body and brain in ways that can't

host of problems , including increased risk of obesity, insulin resistance, heart disease, and chronic inflammation time-restricted feeding were protected  from obesity, excess amounts of insulin in their blood, and inflammation

More specifically, I look at how different diets impact brain inflammation, learning, and memory in multiple inflammation in the brain. Again, these inflammatory signals are likely communicated to the brain, resulting in brain inflammation This is because aged mammals display chronic, low-grade inflammation, even in the absence of disease. Potential Tools to Lessen Inflammation First, we should all try to limit the intake of these inflammatory

interesting, as studies by other research teams have shown that this type of bacteria is associated with inflammation researchers found elevated Prevotella in people with rheumatoid arthritis, a disease in which the joints are inflamed found that specific gut taxa, including Prevotella and Dialister, are associated with cortisol and inflammatory cortisol (a stress hormone) and proinflammatory cytokines (substances secreted by immune cells that cause inflammation that Liisa wanted to share an insight into her work in childhood adversity, the gut microbiome and inflammation

these diseases develop following exposure to pesticides, animal studies suggest that they might cause inflammation Inflammation is a new frontier in mental health research. Inflammation itself, is a natural process by our bodies in response to changes and stresses in the environment

this mechanism, it may help many women experiencing conditions that vary with stress, like migraine, inflammatory Another interesting avenue of research is the role of inflammation in chronic epilepsy. well-known link in depression, the concept that brain or peripheral (outside the central nervous system) inflammation And as we know, chronic stress can result in a maladaptive inflammatory response. We hope to be able to investigate the connections between stress, inflammation and drug resistance in

Given the brain’s infamous complexity, changes in brain activity associated with anhedonia are likely What about inflammation? One example is inflammation, and particularly inflammatory molecules called cytokines, which are known of new generated neurons in the brain, and indeed, this may be one of the mechanisms through which inflammation

For example, I found how increased inflammation and less hippocampal neurogenesis (i.e., the birth of For example, I found that physical stress promoted anxiety, decreased inflammation, overactivated the stress system, increased brain inflammation, and decreased hippocampal neurogenesis. system, decreased brain inflammation and increased hippocampal neurogenesis. , but resulted in yet another profile, one characterised by increased anxiety, decreased inflammation

cortisol (known as the ‘stress hormone’) or triggered by the awakening of latent virus, producing chronic inflammation At Amsterdam UMC, I am co-PI, together with my colleague Femke Lamers, of the INFLAMED clinical trial testing the efficacy of anti-inflammatory add-on in the treatment of what we call “immuno-metabolic form of depression characterized by signs and symptoms very similar to those I experienced such as inflammation These days, I’m returning to my work at INFLAMED with the only useful insight I distilled from this otherwise