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Given the brain’s infamous complexity, changes in brain activity associated with anhedonia are likely What about inflammation? One example is inflammation, and particularly inflammatory molecules called cytokines, which are known of new generated neurons in the brain, and indeed, this may be one of the mechanisms through which inflammation

cortisol (known as the ‘stress hormone’) or triggered by the awakening of latent virus, producing chronic inflammation At Amsterdam UMC, I am co-PI, together with my colleague Femke Lamers, of the INFLAMED clinical trial testing the efficacy of anti-inflammatory add-on in the treatment of what we call “immuno-metabolic form of depression characterized by signs and symptoms very similar to those I experienced such as inflammation These days, I’m returning to my work at INFLAMED with the only useful insight I distilled from this otherwise

By referring to being sick throughout the passage I mean either having the flu, a bug or inflammation The resulting inflammation causes fatigue, low mood, low fever, pain all over the body and other exciting Inflammation is the body’s function of fighting against harmful “invaders” from injuries, infections As a result, inflammation can disrupt your mood as well. A nicely explained article written by Dr Nettis about inflammation and sickness behaviour at InSPIre

For example, we have seen that microbial imbalance in the gut can increase the production of inflammatory butyrate — an essential short-chain fatty acid (SCFA) that maintains a healthy gut lining and prevents inflammation enriched in patients, is involved in butyrate depletion and has also been linked to gastrointestinal inflammation Interestingly, these conditions have also been shown to have an overlap in genetic studies and inflammatory that — I am conducting the PROMEX study to assess how probiotics affect the gut microbiota itself, inflammation

I was diagnosed with inflammatory bowel disease in 2015. Ulcerative colitis, to be precise, which is a form of IBD that causes severe inflammation in your colon The histology report showed that my bowel was severely distended and inflamed, and they removed the entire Having inflammatory bowel disease is hard — it’s completely different to IBS and is life-threatening. A realisation into how deeply inflammatory bowel disease can affect you; not just physically, but mentally

structure that nourishes the unborn baby and removes waste) and reach the fetal brain, where they can cause inflammation Inflammation is the body’s natural defense mechanism but when it reaches the brain, it can be associated Exposure to multiple substances along with infection could induce a chronic inflammatory state.

University that showed L-DOPA administration to patients with depression displaying high levels of inflammation

of many other diseases defined by western medicine, based on modern pharmacological studies, such as inflammation pregnancy (“a liver condition that occurs in late pregnancy”), and even to non-liver diseases, such as inflammatory bowel diseases (“long-term conditions that involve inflammation of the gut”).

A third is that Spring is a time when inflammation increases as plants release pollen, and there have long been associations between mood disorders and inflammation.

, and a specific aspect of inflammation called the ‘kynurenine pathway’. about the role of inflammation in the pathophysiology of both cancer and depression. Cancer is associated with immune abnormalities, and inflammation is pivotal in cancer development. activated, and many depressed patients have high inflammation. But which anti-inflammatories? Which bits of inflammation are important in causing depression?

Uncut,” is an award-winning installation and participatory performance, focusing on depression, blood inflammation was donated to the project in exchange for a sip of anti-inflammatory beetroot juice; their regrets were The installation was inspired by Carmine’s research on blood inflammation in depressed patients and two

We also know that psychotherapy affects the chronic low-grade inflammation seen in depression, although that psychological therapy led to lower levels of c-reactive protein (CRP), a substance produced in inflammation