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Treatment-resistant patients, in particular, are known for having higher levels of inflammation. Right, but the problem with inflammation is that it typically is considered bad news for neurogenesis Interestingly, ECT has been reported to increase markers of inflammation in the blood of patients and This way, we could observe how both neurogenesis and inflammation were affected by ECT. directly after treatment but tends to slowly lower baseline inflammation, meaning right before ECT,

“While there is overwhelming evidence of increased inflammation in depression it is still unclear how As also discussed in our blog, inflammation and stress-related responses in depression have been an area Sixteen inflammation and stress-related genes have been measured in this study, some of which have never : not every person with depression will exhibit heightened inflammation. Considering this link and the findings of this study, targeting inflammation appears to be a viable avenue

The answer was simple: inflammation. Body inflammation is regulated by our immune system, the defensive response which protects us against This seems to suggest that in patients with depression, similarly to those with Alzheimer’s, blood inflammation develop depression, and that is why this clinical model has been used for years to study the effect of inflammation The answer, again, was simple: inflammation.

could reach the brain and become brain inflammation. the presence of inflammation in the brain, too? inflammation in healthy men. , and brain inflammation with PET imaging and with MRI. the effect of inflammation on water and tissues.

But what is inflammation in this context? There are two types of inflammation: acute and chronic. People are most familiar with acute inflammation which is the one that gives redness, warmth, swelling and this is what I will refer to as inflammation in this blog. Laboratory experiments have shown that the P2X7 receptor can trigger inflammation and drugs that block We believe that inflammation of the brain can cause depression in some people and that a drug blocking

Is inflammation the link between depression and cognitive difficulties?' However, some individuals experience chronic, low-grade inflammation (where parts of the immune system , but 50% of all deaths are attributable to inflammation-related diseases. Beyond the direct impact of chronic inflammation on human health, low-grade inflammation is known to Some of my own research has sought to shine a light on how inflammation could be linked with cognitive

But we need research to help us find out… Inflammation In the early stages of my career, I focussed on However sometimes, when there is too much inflammation, this can disrupt the very processes that carry Heart disease is known to be an inflammatory condition and long-term inflammation in the body can potentially We now know that individuals who have both inflammation and depression tend to be those who are less overview of antidepressant properties of ketamine as well as its effects on inflammation.

on the topic - as well as my research investigating how biological markers, specifically increased inflammation adults, we know that chronically higher levels of the stress hormone, cortisol, and chronic low-grade inflammation We also found that increased inflammation in the body and some changes in brain function, like lower The idea was to look at whether inflammation in the body, measured by proteins present in the blood called IL-2 and IL-6 are both produced when there is inflammation, although, they also differ in what they do

The link between stress, inflammation, depression and AQP4 It has been known for a while now that both stress and inflammation are important parameters in depression. One possible way for stress and inflammation to cause this condition is through decreasing neurogenesis Animal studies First of all, we looked at studies performed on mice exposed to stress or inflammation Exposing animals to stress and inflammation usually decreased the levels of AQP4 in their brains.

Now a little bit about depression in the context of inflammation, since this was what primarily ignited Over the past few decades, clinical studies have shown that increased systemic inflammation (measured As the activity of the endocannabinoid system increases, it reduces inflammation. inflammation. I was curious and the questions I asked myself were whether increased systemic inflammation increased

Though we do still have some way to go, researchers have identified a promising avenue: inflammation. Inflammation is the biological process by which your immune system responds to injury or infection (such to their antipsychotic medication, unlike those who had typical levels of inflammation who appeared With this in mind, researchers have taken the logical next step: targeting this inflammation with the The mechanisms through which peripheral (outside of the central nervous system (CNS)) inflammation could

doses of EPA and DHA, first in patients and then in lab-grown neurones, to help clarify how they reduce inflammation have been using this experimental model for years as it perfectly mimics inflammation in the brain of the breakdown of EPA and DHA in the body could be targeted as a mechanism to reduce depression and inflammation disorders, such as depression, where at least a sub-group of patients often have chronic levels of inflammation There is an ever-growing interest in the links between the immune system, inflammation, and depression